Harlem DOT for LTBI Study
We designed a study that examined TB knowledge among patients beginning
Directly Observed Therapy for LTBI, and the impact of these parameters
on adherence with treatment. We assessed patients' demographics,
substance use, TB knowledge, and treatment adherence in the Harlem "surrogate family" clinic-based DOPT program. Of 89 patients,
76% were African-American, 15% Latino, 45% foreign-born, mean age
of 44 years, 38% had a history of homelessness, 42% had completed
high school, 68% had a history of substance use, 27% were currently
using illicit drugs, and 10% were previously treated for LTBI. At
baseline, 67% of patients had known HIV status with 23% HIV positive.
Overall, treatment adherence with doses was 96%, with 77% of patients
taking >95% of prescribed medications. Of twenty-four questions
regarding TB knowledge, 15.2% of patients with adherence >95%
and 16.7% of patients with adherence <95% answered correctly
75% or more of questions with mean score of 15.7. Patients had similar
TB knowledge scores regardless of adherence or HIV status.